Angular analysis of corpus callosum in 18 patients with frontonasal dysplasia

• Main Authors: Giffoni Silvyo David Araújo, Gonçalves Vanda Maria Gimenes, Zanardi Verônica A., Lopes Vera Lúcia Gil da Silva
• Format: Article
• Language: English
• Published: Academia Brasileira de Neurologia (ABNEURO) 2004-01-01
• Series: Arquivos de Neuro-Psiquiatria
• Subjects: corpus callosum; frontonasal dysplasia; magnetic resonance image; midline facial cleft
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000200001
• ISSN: 0004-282X; 1678-4227

Considering the rarity of the frontonasal dysplasia (FD) and the few reports about it in a large casuistry using magnetic resonance image (MRI), we describe the results of the angular analysis of the corpus callosum of 18 individuals with FD (7 male, 11 female), using an easily-reproductive method. Group I had 12 individuals with isolated form and Group II had 6 individuals with FD syndromic with unknown etiology. The results are presented in set. Comparing with the control group, patients with FD presented alpha angle increase and beta and gamma angles reduction (p<0.05). Alpha and gamma angles express the relationship between the anterior portion of corpus callosum and the floor of 4th ventricle. Considering the embryonary development, these findings would occur secondarily to failure during the development of nasal capsula. Thus, angular anomaly in corpus callosum would be a usual finding, and not fortuitous in patients with FD.