TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy

TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Abstract Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a genetic cardiac muscle disease that accounts for approximately 30% sudden cardiac death in young adults. The Ser358Leu mutation of transmembrane protein 43 (TMEM43) was commonly identified in the patients of highly leth...

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Bibliographic Details
Main Authors: Guoxing Zheng, Changying Jiang, Yulin Li, Dandan Yang, Youcai Ma, Bing Zhang, Xuan Li, Pei Zhang, Xiaoyu Hu, Xueqiang Zhao, Jie Du, Xin Lin
Format: Article
Language:English
Published: SpringerOpen 2018-07-01
Series:Protein & Cell
Subjects:
TMEM43
ARVD
NF-κB
TGFβ
fibrosis
knock-in mouse
Online Access:http://link.springer.com/article/10.1007/s13238-018-0563-2

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http://link.springer.com/article/10.1007/s13238-018-0563-2

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