Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets

Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets

Tumor suppressors play an important role in cancer pathogenesis and in the modulation of resistance to treatments. Loss of function of the proteins encoded by tumor suppressors, through genomic inactivation of the gene, disable all the controls that balance growth, survival, and apoptosis, promoting...

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Bibliographic Details
Main Authors: Giacomo Andreani, Giovanna Carrà, Marcello Francesco Lingua, Beatrice Maffeo, Mara Brancaccio, Riccardo Taulli, Alessandro Morotti
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
chronic lymphocytic leukemia
tumor suppressors
mutations
deletions
epigenetics
mirna
p53
pten
Online Access:https://www.mdpi.com/2072-6694/12/3/629

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