Microwave-assisted synthesis of 2-substituted 4,5,6,7-tetrahydro-1,3-thiazepines from 4-aminobutanol

Microwave-assisted synthesis of 2-substituted 4,5,6,7-tetrahydro-1,3-thiazepines from 4-aminobutanol

A general procedure for the synthesis of 2-substituted tetrahydro-1,3-thiazepines by MW-assisted cyclization of 4-thioamidobutanols is presented. The acyclic precursors were prepared in high overall yields by an expeditious three-step diacylation/thionation/deprotection sequence from 4-aminobutanol....

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Bibliographic Details
Main Authors: María C. Mollo, Natalia B. Kilimciler, Juan A. Bisceglia, Liliana R. Orelli
Format: Article
Language:English
Published: Beilstein-Institut 2020-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cyclodehydration
medium-size heterocycles
microwaves
ppse
tetrahydrothiazepines
Online Access:https://doi.org/10.3762/bjoc.16.5

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