Airway function indicators and blood indicators in children with dust mite allergic rhinitis after sublingual immunotherapy
Objective: To evaluate the airway function indicators and blood indicators in children with dust mite allergic rhinitis after sublingual immunotherapy. Methods: A total of 68 children with dust mite allergic rhinitis treated in our hospital from November, 2012 to October, 2015 were selected as th...
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-07-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201613/29.pdf |
| Summary: | Objective: To evaluate the airway function indicators and blood indicators in children with
dust mite allergic rhinitis after sublingual immunotherapy. Methods: A total of 68 children
with dust mite allergic rhinitis treated in our hospital from November, 2012 to October, 2015
were selected as the research subjects and randomly divided into observation group 34 cases
and control group 34 cases. The control group received clinical routine therapy for allergic
rhinitis, the observation group received sublingual immunotherapy, and then differences in
basic lung function indicator values, small airway function indicator values and levels of serum
inflammatory factors as well as serum ECP, TARC, Eotaxin-2 and VCAM were compared
between two groups after treatment. Results: The FVC, FEV1, PEF and FEV1/FVC values of
the observation group after treatment were higher than those of the control group (P<0.05); the
MMEF, MEF50% and MEF25% values of the observation group were higher than those of the
control group, and the proportion of AHR was lower than that of the control group (P<0.05);
the serum IL-4, IL-9, IL-12, IL-13 and IL-16 levels of the observation group after treatment
were lower than those of the control group, and the IL-10 and IL-12 levels are higher than
those of the control group (P<0.05); the serum ECP, TARC, Eotaxin-2 and VCAM levels of the
observation group children after treatment were lower than those of the control group (P<0.05).
Conclusions: Sublingual immunotherapy for children with dust mite allergic rhinitis can
optimize the airway function, reduce the systemic inflammatory response and eventually
improve the children’s overall state, and it’s has positive clinical significance. |
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| ISSN: | 1007-1237 1007-1237 |