Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.

We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-depen...

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Main Authors:	Anita Mehta, Jean-Marc Luck, Collin C Luk, Naweed I Syed
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3812211?pdf=render

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spelling	doaj-027f1a81ffd549c6bb9ed050256e7f372020-11-25T02:42:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7805610.1371/journal.pone.0078056Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.Anita MehtaJean-Marc LuckCollin C LukNaweed I SyedWe present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.http://europepmc.org/articles/PMC3812211?pdf=render
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anita Mehta Jean-Marc Luck Collin C Luk Naweed I Syed
spellingShingle	Anita Mehta Jean-Marc Luck Collin C Luk Naweed I Syed Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm. PLoS ONE
author_facet	Anita Mehta Jean-Marc Luck Collin C Luk Naweed I Syed
author_sort	Anita Mehta
title	Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
title_short	Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
title_full	Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
title_fullStr	Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
title_full_unstemmed	Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
title_sort	synaptic metaplasticity underlies tetanic potentiation in lymnaea: a novel paradigm.
publisher	Public Library of Science (PLoS)
series	PLoS ONE
issn	1932-6203
publishDate	2013-01-01
description	We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.
url	http://europepmc.org/articles/PMC3812211?pdf=render
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Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.

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