Long non-coding RNA LINC00473 acts as a microRNA-29a-3p sponge to promote hepatocellular carcinoma development by activating Robo1-dependent PI3K/AKT/mTOR signaling pathway

Long non-coding RNA LINC00473 acts as a microRNA-29a-3p sponge to promote hepatocellular carcinoma development by activating Robo1-dependent PI3K/AKT/mTOR signaling pathway

Background: Long non-coding RNAs have suppressive or oncogenic effects in various types of cancers by serving as competing endogenous RNAs for specific microRNAs. In the present study, we aim to delineate the underlying mechanism by which the LINC00473/miR-29a-3p/Robo1 axis affects cell proliferatio...

Full description

Bibliographic Details
Main Authors:	Qiqin Song, Hongyue Zhang, Jinan He, Hongyan Kong, Ran Tao, Yu Huang, Haijing Yu, Zhongwei Zhang, Zhiyong Huang, Lai Wei, Chenghai Liu, Likui Wang, Qin Ning, Jiaquan Huang
Format:	Article
Language:	English
Published:	SAGE Publishing 2020-08-01
Series:	Therapeutic Advances in Medical Oncology
Online Access:	https://doi.org/10.1177/1758835920937890

Similar Items

LINC00473 promotes hepatocellular carcinoma progression via acting as a ceRNA for microRNA-195 and increasing HMGA2 expression
by: Jinggang Mo, et al.
Published: (2019-12-01)

LncRNA LINC00473 is involved in the progression of invasive pituitary adenoma by upregulating KMT5A via ceRNA-mediated miR-502-3p evasion
by: Junjun Li, et al.
Published: (2021-06-01)

LINC00473 as an Immediate Early Gene under the Control of the EGR1 Transcription Facto
by: Vincenza Aliperti, et al.
Published: (2020-11-01)

Linc00473 potentiates cholangiocarcinoma progression by modulation of DDX5 expression via miR-506 regulation
by: Lining Huang, et al.
Published: (2020-07-01)

Knockdown of LINC00473 Enhances Radiosensitivity in Hepatocellular Carcinoma via Regulating the miR-345-5p/FOXP1 Axis
by: Zhang Y, et al.
Published: (2020-01-01)

Long Noncoding RNA 00473 Is Involved in Preeclampsia by LSD1 Binding-Regulated TFPI2 Transcription in Trophoblast Cells
by: Dan Wu, et al.
Published: (2018-09-01)

Long intergenic non-coding RNA 00473 promotes proliferation and migration of gastric cancer via the miR-16-5p/CCND2 axis and by regulating AQP3
by: Shuaishuai Zhuo, et al.
Published: (2021-05-01)

Endothelin receptors promote schistosomiasis-induced hepatic fibrosis via splenic B cells.
by: Hongyan Kong, et al.
Published: (2020-10-01)

Long Non-coding RNA LINC00115 Contributes to the Progression of Colorectal Cancer by Targeting miR-489-3p via the PI3K/AKT/mTOR Pathway
by: Weiyu Feng, et al.
Published: (2020-09-01)

LINC01420 RNA structure and influence on cell physiology
by: Daria O. Konina, et al.
Published: (2019-05-01)

LINC00473 regulated apoptosis, proliferation and migration but could not reverse cell cycle arrest of human bone marrow mesenchymal stem cells induced by a high-dosage of dexamethasone
by: Yingxing Xu, et al.
Published: (2020-10-01)

LINC00261: a burgeoning long noncoding RNA related to cancer
by: Menggang Zhang, et al.
Published: (2021-05-01)

LncRNA LINC00461 Promotes Colorectal Cancer Progression via miRNA-323b-3p/NFIB Axis
by: Yu H, et al.
Published: (2019-12-01)

Comprehensive analysis of ceRNA network related to lincRNA in glioblastoma and prediction of clinical prognosis
by: Guangdong Liu, et al.
Published: (2021-01-01)

LncRNA PTCSC3 Inhibits Tumor Growth and Cancer Cell Stemness in Gastric Cancer by Interacting with lncRNA Linc-pint
by: Hong L, et al.
Published: (2019-12-01)

Comparative analysis of lincRNA in insect species
by: Alberto Lopez-Ezquerra, et al.
Published: (2017-07-01)

LncRNA LINC00588 Suppresses the Progression of Osteosarcoma by Acting as a ceRNA for miRNA-1972
by: Fu-Chao Zhou, et al.
Published: (2020-03-01)

Long noncoding RNA LINC01410 promotes the tumorigenesis of neuroblastoma cells by sponging microRNA‐506‐3p and modulating WEE1
by: Jie Mi, et al.
Published: (2020-11-01)

Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation
by: Manyi Wei, et al.
Published: (2021-05-01)

Downregulation of long noncoding RNA LINC01419 inhibits cell migration, invasion, and tumor growth and promotes autophagy inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer
by: Lin-Lin Wang, et al.
Published: (2019-09-01)

LINC00472 Acts as a Tumor Suppressor in NSCLC through KLLN-Mediated p53-Signaling Pathway via MicroRNA-149-3p and MicroRNA-4270
by: Aimei Zou, et al.
Published: (2019-09-01)

LINC01089 functions as a ceRNA for miR-152-3p to inhibit non‐small lung cancer progression through regulating PTEN
by: Huixian Zhang, et al.
Published: (2021-03-01)

LINC00504 Promotes the Malignant Biological Behavior of Breast Cancer Cells by Upregulating HMGB3 via Decoying MicroRNA-876-3p
by: Yu H, et al.
Published: (2021-02-01)

Advances in Mechanism of LincRNA-p21 in Cancer
by: ZHAO Suyue, et al.
Published: (2020-10-01)

LincRNA-p21: Implications in Human Diseases
by: Sai-Sai Tang, et al.
Published: (2015-08-01)

The long noncoding RNA LINC00483 promotes lung adenocarcinoma progression by sponging miR-204-3p
by: Shengzhuang Yang, et al.
Published: (2019-12-01)

Bioinformatics Analysis of DNA Methylation in the Promoters of LincRNA  in Lung Adenocarcinoma
by: Wen ZHANG, et al.
Published: (2018-06-01)

Overexpression of long noncoding RNA LINC00882 is associated with poor prognosis in hepatocellular carcinoma
by: Zhu L, et al.
Published: (2018-09-01)

Long Non-coding RNA LINC00628 Interacts Epigenetically with the LAMA3 Promoter and Contributes to Lung Adenocarcinoma
by: Shu-Feng Xu, et al.
Published: (2019-12-01)

CircRNA-100338 Is Associated With mTOR Signaling Pathway and Poor Prognosis in Hepatocellular Carcinoma
by: Xiu-Yan Huang, et al.
Published: (2019-05-01)

Effect of LncRNA LINC00475 on biological behaviors of glioma cells
by: ZHANG Delong, et al.
Published: (2019-02-01)

ZBTB7A Enhances Osteosarcoma Chemoresistance by Transcriptionally Repressing lncRNALINC00473-IL24 Activity
by: Lu Zhang, et al.
Published: (2017-11-01)

The lncRNA LINC00691 Functions as a ceRNA for miRNA-1256 to Suppress Osteosarcoma by Regulating the Expression of ST5
by: Wan D, et al.
Published: (2020-12-01)

Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer
by: Xin Wang, et al.
Published: (2020-12-01)

SNP@lincTFBS: an integrated database of polymorphisms in human LincRNA transcription factor binding sites.
by: Shangwei Ning, et al.
Published: (2014-01-01)

Long Noncoding RNA LINC00839 Promotes the Malignant Progression of Osteosarcoma by Competitively Binding to MicroRNA-454-3p and Consequently Increasing c-Met Expression
by: Zhang Y, et al.
Published: (2020-09-01)

TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice
by: Xiaolong Tu, et al.
Published: (2017-06-01)

A deep learning method for lincRNA detection using auto-encoder algorithm
by: Ning Yu, et al.
Published: (2017-12-01)

The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers
by: Yan Pan, et al.
Published: (2016-11-01)

RNA-Seq Implies Divergent Regulation Patterns of LincRNA on Spermatogenesis and Testis Growth in Goats
by: Dongdong Bo, et al.
Published: (2021-02-01)