Bevacizumab Induces Upregulation of Keratin 3 and VEGFA in Human Limbal Epithelial Cells in Vitro

Bevacizumab Induces Upregulation of Keratin 3 and VEGFA in Human Limbal Epithelial Cells in Vitro

Topical application of vascular endothelial growth factor A (VEGFA) inhibitors including Bevacizumab is used for antiangiogenic therapy at the ocular surface. While clinical studies have suggested that this approach is well-tolerated, the effect of the drug on limbal epithelial stem cells has not be...

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Bibliographic Details
Main Authors: Maria Notara, Anna Lentzsch, Thomas Clahsen, Sara Behboudifard, Gabriele Braun, Claus Cursiefen
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Journal of Clinical Medicine
Subjects:
bevacizumab
limbal epithelial cells
stem cells
keratin 3
Online Access:https://www.mdpi.com/2077-0383/8/11/1925

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