CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

• Main Authors: Ye. D. Bazdyrev, Ye. B. Gerasimova, O. M. Polikutina, I. A. Savelieva, S. A. Smakotina, O. L. Barbarash
• Format: Article
• Language: Russian
• Published: ABV-press 2014-11-01
• Series: Klinicist
• Subjects: chronic obstructive pulmonary disease; arterial hypertension
• Online Access: http://klinitsist.abvpress.ru/index.php/Klin/article/view/143

<p><strong>Objective:</strong> to detect previously undiagnosed arterial hypertension in patients with chronic obstructive pulmonary disease (COPD) as a risk factor for cardiovascular mortality.</p><p><strong>Materials and methods.</strong> 43 patients with stage I–II of COPD and the absence of clinical signs of cardiovascular diseases were examined. Spirometry, body plethysmography and diffusing lung capacity (DLCO) were included in the respiratory system assessment. The cardiovascular system was assessed with echocardiography and ambulatory blood pressure monitoring (ABPM).</p><p><strong>Results.</strong> Despite the absence of obvious signs of cardiovascular lesions (an increase of office blood pressure, intracardiac hemodynamic changes), the following cardiovascular risk factors were identified: age (58.2 ± 2.0 years), male gender, smoking, hypercholesterolemia and dyslipidemia (total cholesterol 5.9 ± 0.9 mmol / l, low density lipoproteins 3.8 ± 0.5 mmol / l, triglycerides 1.8 ± 0.2 mmol / l). Correlation analysis has revealed the relation between several respiratory parameters and the severity of dyspnea and quality of life in patients with COPD, as well as its relation with lipid levels.</p><p><strong>Conclusion.</strong> The patients with COPD have a large number of risk factors for CVD. According to ABPM data, arterial hypertension was verified in 18 (41.9 %) of 43 patients with COPD at normal level of office blood pressure; moreover, 51.2 % of patients demonstrated low reduction of blood pressure during the night-time that nowadays, is considered to be a predictor of cardiovascular disease and sudden death.</p>