PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet

PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet

Oxidative stress and excessive lipid accumulation in liver tissues are considered as important factors in development of non-alcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease worldwide and strongly associated with insulin resistance, obesity and dyslipidemia. In t...

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Main Authors: Zunli Ke, Ziyan Zhao, Yuanyuan Zhao, Xiaodan Xu, Yin Li, Si Tan, Cheng Huang, Zhiqin Zhou
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Journal of Functional Foods
Subjects:
Oxidative stress
Non-alcoholic fatty liver disease
PMFs
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618302494
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spelling doaj-0274835440284c5880d1b257866fbb2a2021-04-30T07:13:54ZengElsevierJournal of Functional Foods1756-46462018-08-01472839PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat dietZunli Ke0Ziyan Zhao1Yuanyuan Zhao2Xiaodan Xu3Yin Li4Si Tan5Cheng Huang6Zhiqin Zhou7College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China; Drug Discovery Lab, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, ChinaCollege of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, ChinaDrug Discovery Lab, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCollege of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, ChinaDrug Discovery Lab, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaLife Science and Technology Institute, Yangtze Normal University, Fuling, 408100 Chongqing, ChinaDrug Discovery Lab, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Corresponding authors at: College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China (Z. Zhou).College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, China; Corresponding authors at: College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China (Z. Zhou).Oxidative stress and excessive lipid accumulation in liver tissues are considered as important factors in development of non-alcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease worldwide and strongly associated with insulin resistance, obesity and dyslipidemia. In this study, the effect of PMFs-enriched extract of Daoxianyeju (Citrus daoxianensis S.W. He) (EDX) on NAFLD were examined using high fat diet-induced obesity (DIO) C57BL/6 mice. Daily supplementation of 0.2% and 0.5% EDX with high fat diet (w/w) over ten weeks markedly improved glucose tolerance and insulin resistance as well as lipid profiles, alleviated hepatic steatosis, inflammatory and oxidative stress. The benefit of EDX on improving pathology of NAFLD induced by high fat diet may associate with the activation of nuclear factor erythroid-2 related factor 2 (Nrf2) pathways in liver tissues. Our study showed that citrus PMFs may use as a dietary therapy for NAFLD and related metabolic disorders.http://www.sciencedirect.com/science/article/pii/S1756464618302494Oxidative stressNon-alcoholic fatty liver diseasePMFsNrf2
collection DOAJ
language English
format Article
sources DOAJ
author Zunli Ke
Ziyan Zhao
Yuanyuan Zhao
Xiaodan Xu
Yin Li
Si Tan
Cheng Huang
Zhiqin Zhou
spellingShingle Zunli Ke
Ziyan Zhao
Yuanyuan Zhao
Xiaodan Xu
Yin Li
Si Tan
Cheng Huang
Zhiqin Zhou
PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
Journal of Functional Foods
Oxidative stress
Non-alcoholic fatty liver disease
PMFs
Nrf2
author_facet Zunli Ke
Ziyan Zhao
Yuanyuan Zhao
Xiaodan Xu
Yin Li
Si Tan
Cheng Huang
Zhiqin Zhou
author_sort Zunli Ke
title PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
title_short PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
title_full PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
title_fullStr PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
title_full_unstemmed PMFs-rich Citrus extract prevents the development of non-alcoholic fatty liver disease in C57BL/6J mice induced by a high-fat diet
title_sort pmfs-rich citrus extract prevents the development of non-alcoholic fatty liver disease in c57bl/6j mice induced by a high-fat diet
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2018-08-01
description Oxidative stress and excessive lipid accumulation in liver tissues are considered as important factors in development of non-alcoholic fatty liver disease (NAFLD), which is the most common chronic liver disease worldwide and strongly associated with insulin resistance, obesity and dyslipidemia. In this study, the effect of PMFs-enriched extract of Daoxianyeju (Citrus daoxianensis S.W. He) (EDX) on NAFLD were examined using high fat diet-induced obesity (DIO) C57BL/6 mice. Daily supplementation of 0.2% and 0.5% EDX with high fat diet (w/w) over ten weeks markedly improved glucose tolerance and insulin resistance as well as lipid profiles, alleviated hepatic steatosis, inflammatory and oxidative stress. The benefit of EDX on improving pathology of NAFLD induced by high fat diet may associate with the activation of nuclear factor erythroid-2 related factor 2 (Nrf2) pathways in liver tissues. Our study showed that citrus PMFs may use as a dietary therapy for NAFLD and related metabolic disorders.
topic Oxidative stress
Non-alcoholic fatty liver disease
PMFs
Nrf2
url http://www.sciencedirect.com/science/article/pii/S1756464618302494
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