Hormonal and metabolic effects of polyunsaturated fatty acid (omega-3) on polycystic ovary syndrome induced rats under diet

• Main Authors: Elaheh Ouladsahebmadarek, Arash Khaki, Sharareh Khanahmadi, Hamidreza Ahmadi Ashtiani, Pooya Paknejad, Mohammad Reza Ayubi
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2014-02-01
• Series: Iranian Journal of Basic Medical Sciences
• Subjects: Catalaze (CAT); Follicle stimulating hormone (FSH); Glutathione peroxidase (GPX); Omega-3; Polycystic ovary (PCO); Super oxide dismutase (SOD); Testosterone
• Online Access: http://ijbms.mums.ac.ir/pdf_2245_ab05951f0c21d1f49c4af9420ca8d902.html

Objective(s): PCOS (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing omega-3 (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats. Materials and Methods: Wistar female rats (n=40) were allocated into control (n=10) and test groups (n= 30), test group was subdivided into 3 groups: G1, received omega-3 (240 mg/kg/orally/daily); G2 and G3 groups were induced PCO by single injection of estradiol-valerate (16 mg/kg/IM). Group 3 received omega-3 (240 mg/kg/orally/daily) and low carbohydrate feeding for 60 subsequent days; on sixtieth day 5 ml blood samples and ovarian tissues of all rats in the group were removed and prepared for biochemical and hormonal analysis. Results: Catalase, GPX (Glutathione peroxidase), SOD (Superoxide dismutase) in groups that received omega-3showed higher levels, but MDA (malondialdehyde) level was significantly decreased (P