Scanning mutagenesis of the amino acid sequences flanking phosphorylation site 1 of the mitochondrial pyruvate dehydrogenase complex

Scanning mutagenesis of the amino acid sequences flanking phosphorylation site 1 of the mitochondrial pyruvate dehydrogenase complex

The mitochondrial pyruvate dehydrogenase complex is regulated by reversible seryl-phosphorylation of the E1α subunit by a dedicated, intrinsic kinase. The phospho-complex is reactivated when dephosphorylated by an intrinsic PP2C-type protein phosphatase. Both the position of the phosphorylated Ser...

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Bibliographic Details
Main Authors: Nagib eAhsan, Kirby eSwatek, Jingfen eZhang, Ján Andrew Miernyk, Dong eXu, Jay eThelen
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Plant Science
Subjects:
Pyruvate Dehydrogenase Complex
KiC assay
mass specrometry
mitochondrial
phosphorylation site
synthetic peptides
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpls.2012.00153/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpls.2012.00153/full

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