High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice

High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice

The accumulation of human islet amyloid polypeptide (hIAPP) in pancreatic islets under induction by a high-fat diet plays a critical role in the development of type-2 diabetes mellitus (T2DM). T2DM is a risk factor of late-onset Alzheimer’s disease (AD). Nevertheless, whether hIAPP in combination wi...

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Bibliographic Details
Main Authors: Xiao-Xia Xi, Jing Sun, Hai-Chao Chen, An-Di Chen, Li-Ping Gao, Jie Yin, Yu-Hong Jing
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
human islet amyloid polypeptide
high-fat diet
hippocampus
cognition
brain aging
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00225/full

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