The i-Motif as a Molecular Target: More than a Complementary DNA Secondary Structure
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences...
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MDPI AG
2021-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/2/96 |
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doaj-024f86d45e184cf18b33c0f006865d552021-01-28T00:01:44ZengMDPI AGPharmaceuticals1424-82472021-01-0114969610.3390/ph14020096The i-Motif as a Molecular Target: More than a Complementary DNA Secondary StructureSusie L. Brown0Samantha Kendrick1Biochemistry and Molecular Biology Department, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USABiochemistry and Molecular Biology Department, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USAStretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences may play a role in facilitating or hindering expansion of these DNA elements. Despite research on the i-motif trailing behind the complementary G-quadruplex structure, recent discoveries including the identification of a specific i-motif antibody are pushing this field forward. This perspective reviews initial and current work characterizing the i-motif and providing insight into the biological function of this DNA structure, with a focus on how the i-motif can serve as a molecular target for developing new therapeutic approaches to modulate gene expression and extension of repetitive DNA.https://www.mdpi.com/1424-8247/14/2/96i-motifDNA quadruplex structurestranscription regulationcancer therapeutics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Susie L. Brown Samantha Kendrick |
| spellingShingle |
Susie L. Brown Samantha Kendrick The i-Motif as a Molecular Target: More than a Complementary DNA Secondary Structure Pharmaceuticals i-motif DNA quadruplex structures transcription regulation cancer therapeutics |
| author_facet |
Susie L. Brown Samantha Kendrick |
| author_sort |
Susie L. Brown |
| title |
The i-Motif as a Molecular Target: More than a Complementary DNA Secondary Structure |
| title_short |
The i-Motif as a Molecular Target: More than a Complementary DNA Secondary Structure |
| title_full |
The i-Motif as a Molecular Target: More than a Complementary DNA Secondary Structure |
| title_fullStr |
The i-Motif as a Molecular Target: More than a Complementary DNA Secondary Structure |
| title_full_unstemmed |
The i-Motif as a Molecular Target: More than a Complementary DNA Secondary Structure |
| title_sort |
i-motif as a molecular target: more than a complementary dna secondary structure |
| publisher |
MDPI AG |
| series |
Pharmaceuticals |
| issn |
1424-8247 |
| publishDate |
2021-01-01 |
| description |
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences may play a role in facilitating or hindering expansion of these DNA elements. Despite research on the i-motif trailing behind the complementary G-quadruplex structure, recent discoveries including the identification of a specific i-motif antibody are pushing this field forward. This perspective reviews initial and current work characterizing the i-motif and providing insight into the biological function of this DNA structure, with a focus on how the i-motif can serve as a molecular target for developing new therapeutic approaches to modulate gene expression and extension of repetitive DNA. |
| topic |
i-motif DNA quadruplex structures transcription regulation cancer therapeutics |
| url |
https://www.mdpi.com/1424-8247/14/2/96 |
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