Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Macrophages are key innate immune cells in the tumor microenvironment (TME) that regulate primary tumor growth, vascularization, metastatic spread and tumor response to various types of therapies. The present review highlights the mechanisms of macrophage programming in tumor microenvironments that...

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Main Authors:	Irina Larionova, Elena Kazakova, Marina Patysheva, Julia Kzhyshkowska
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	Cancers
Subjects:	tumor-associated macrophages reprogramming tumor metabolism glycolysis fatty acid oxidation
Online Access:	https://www.mdpi.com/2072-6694/12/6/1411

id	doaj-024e8f78367344e69c141e2fa86064bd
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spelling	doaj-024e8f78367344e69c141e2fa86064bd2020-11-25T02:53:45ZengMDPI AGCancers2072-66942020-05-01121411141110.3390/cancers12061411Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated MacrophagesIrina Larionova0Elena Kazakova1Marina Patysheva2Julia Kzhyshkowska3Laboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, RussiaLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, RussiaLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, RussiaLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, RussiaMacrophages are key innate immune cells in the tumor microenvironment (TME) that regulate primary tumor growth, vascularization, metastatic spread and tumor response to various types of therapies. The present review highlights the mechanisms of macrophage programming in tumor microenvironments that act on the transcriptional, epigenetic and metabolic levels. We summarize the latest knowledge on the types of transcriptional factors and epigenetic enzymes that control the direction of macrophage functional polarization and their pro- and anti-tumor activities. We also focus on the major types of metabolic programs of macrophages (glycolysis and fatty acid oxidation), and their interaction with cancer cells and complex TME. We have discussed how the regulation of macrophage polarization on the transcriptional, epigenetic and metabolic levels can be used for the efficient therapeutic manipulation of macrophage functions in cancer.https://www.mdpi.com/2072-6694/12/6/1411tumor-associated macrophagesreprogrammingtumormetabolismglycolysisfatty acid oxidation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Irina Larionova Elena Kazakova Marina Patysheva Julia Kzhyshkowska
spellingShingle	Irina Larionova Elena Kazakova Marina Patysheva Julia Kzhyshkowska Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages Cancers tumor-associated macrophages reprogramming tumor metabolism glycolysis fatty acid oxidation
author_facet	Irina Larionova Elena Kazakova Marina Patysheva Julia Kzhyshkowska
author_sort	Irina Larionova
title	Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
title_short	Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
title_full	Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
title_fullStr	Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
title_full_unstemmed	Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
title_sort	transcriptional, epigenetic and metabolic programming of tumor-associated macrophages
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2020-05-01
description	Macrophages are key innate immune cells in the tumor microenvironment (TME) that regulate primary tumor growth, vascularization, metastatic spread and tumor response to various types of therapies. The present review highlights the mechanisms of macrophage programming in tumor microenvironments that act on the transcriptional, epigenetic and metabolic levels. We summarize the latest knowledge on the types of transcriptional factors and epigenetic enzymes that control the direction of macrophage functional polarization and their pro- and anti-tumor activities. We also focus on the major types of metabolic programs of macrophages (glycolysis and fatty acid oxidation), and their interaction with cancer cells and complex TME. We have discussed how the regulation of macrophage polarization on the transcriptional, epigenetic and metabolic levels can be used for the efficient therapeutic manipulation of macrophage functions in cancer.
topic	tumor-associated macrophages reprogramming tumor metabolism glycolysis fatty acid oxidation
url	https://www.mdpi.com/2072-6694/12/6/1411
work_keys_str_mv	AT irinalarionova transcriptionalepigeneticandmetabolicprogrammingoftumorassociatedmacrophages AT elenakazakova transcriptionalepigeneticandmetabolicprogrammingoftumorassociatedmacrophages AT marinapatysheva transcriptionalepigeneticandmetabolicprogrammingoftumorassociatedmacrophages AT juliakzhyshkowska transcriptionalepigeneticandmetabolicprogrammingoftumorassociatedmacrophages
_version_	1724724669963042816

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

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