Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre

Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre

Following instruction by a morphogen secreting centre, aggregates of mouse embryonic stem cells develop into embryo-like structures organized around an axial mesoderm, which show extensive characteristics of a neurula-stage mouse embryo, with antero-posterior and dorso-ventral patterning of germ lay...

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Main Authors: Peng-Fei Xu, Ricardo Moraes Borges, Jonathan Fillatre, Maraysa de Oliveira-Melo, Tao Cheng, Bernard Thisse, Christine Thisse
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23653-4
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spelling doaj-0246bf48802949329082b7c4d63be7932021-06-06T11:13:54ZengNature Publishing GroupNature Communications2041-17232021-06-0112112210.1038/s41467-021-23653-4Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centrePeng-Fei Xu0Ricardo Moraes Borges1Jonathan Fillatre2Maraysa de Oliveira-Melo3Tao Cheng4Bernard Thisse5Christine Thisse6Department of Cell Biology, University of VirginiaDepartment of Cell Biology, University of VirginiaDepartment of Cell Biology, University of VirginiaDepartment of Cell Biology, University of VirginiaInstitute of Genetics and Department of Genetics, School of Medicine, Zhejiang UniversityDepartment of Cell Biology, University of VirginiaDepartment of Cell Biology, University of VirginiaFollowing instruction by a morphogen secreting centre, aggregates of mouse embryonic stem cells develop into embryo-like structures organized around an axial mesoderm, which show extensive characteristics of a neurula-stage mouse embryo, with antero-posterior and dorso-ventral patterning of germ layer derivatives.https://doi.org/10.1038/s41467-021-23653-4
collection DOAJ
language English
format Article
sources DOAJ
author Peng-Fei Xu
Ricardo Moraes Borges
Jonathan Fillatre
Maraysa de Oliveira-Melo
Tao Cheng
Bernard Thisse
Christine Thisse
spellingShingle Peng-Fei Xu
Ricardo Moraes Borges
Jonathan Fillatre
Maraysa de Oliveira-Melo
Tao Cheng
Bernard Thisse
Christine Thisse
Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
Nature Communications
author_facet Peng-Fei Xu
Ricardo Moraes Borges
Jonathan Fillatre
Maraysa de Oliveira-Melo
Tao Cheng
Bernard Thisse
Christine Thisse
author_sort Peng-Fei Xu
title Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
title_short Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
title_full Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
title_fullStr Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
title_full_unstemmed Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
title_sort construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Following instruction by a morphogen secreting centre, aggregates of mouse embryonic stem cells develop into embryo-like structures organized around an axial mesoderm, which show extensive characteristics of a neurula-stage mouse embryo, with antero-posterior and dorso-ventral patterning of germ layer derivatives.
url https://doi.org/10.1038/s41467-021-23653-4
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