Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study

A potential complication in critically ill patients is the formation of bone in soft tissues, termed heterotopic ossification. The exact pathogenetic mechanisms are still undetermined. Bone morphogenetic proteins induce bone formation, while signalling through the receptor activator of nuclear facto...

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Main Authors:	Vassiliou Alice Georgia, Jahaj Edison, Mastora Zafeiria, Karnezis Ioannis, Dimopoulou Ioanna, Orfanos Stylianos E., Kotanidou Anastasia
Format:	Article
Language:	English
Published:	Sciendo 2021-01-01
Series:	The Journal of Critical Care Medicine
Subjects:	bone morphogenetic proteins critically-ill heterotropic ossification osteoprotegerin receptor activator of nuclear factor kappa-β ligand
Online Access:	https://doi.org/10.2478/jccm-2020-0046

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spelling	doaj-023bcd259be4470c8ee9092a873894bd2021-09-06T19:41:34ZengSciendoThe Journal of Critical Care Medicine2393-18172021-01-0171374510.2478/jccm-2020-0046Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre StudyVassiliou Alice Georgia0Jahaj Edison1Mastora Zafeiria2Karnezis Ioannis3Dimopoulou Ioanna4Orfanos Stylianos E.5Kotanidou Anastasia6First Department of Critical Care Medicine and Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceDepartment of Orthopedics, Evangelismos Hospital, Athens, GreeceFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceFirst Department of Critical Care Medicine and Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceA potential complication in critically ill patients is the formation of bone in soft tissues, termed heterotopic ossification. The exact pathogenetic mechanisms are still undetermined. Bone morphogenetic proteins induce bone formation, while signalling through the receptor activator of nuclear factor kappa-Β (RANK) and its ligand (RANKL), regulates osteoclast formation, activation, and survival in normal bone modelling and remodelling. Osteoprotegerin protects bone from excessive bone loss by blocking RANKL from binding to RANK.https://doi.org/10.2478/jccm-2020-0046bone morphogenetic proteinscritically-illheterotropic ossificationosteoprotegerinreceptor activator of nuclear factor kappa-β ligand
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vassiliou Alice Georgia Jahaj Edison Mastora Zafeiria Karnezis Ioannis Dimopoulou Ioanna Orfanos Stylianos E. Kotanidou Anastasia
spellingShingle	Vassiliou Alice Georgia Jahaj Edison Mastora Zafeiria Karnezis Ioannis Dimopoulou Ioanna Orfanos Stylianos E. Kotanidou Anastasia Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study The Journal of Critical Care Medicine bone morphogenetic proteins critically-ill heterotropic ossification osteoprotegerin receptor activator of nuclear factor kappa-β ligand
author_facet	Vassiliou Alice Georgia Jahaj Edison Mastora Zafeiria Karnezis Ioannis Dimopoulou Ioanna Orfanos Stylianos E. Kotanidou Anastasia
author_sort	Vassiliou Alice Georgia
title	Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study
title_short	Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study
title_full	Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study
title_fullStr	Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study
title_full_unstemmed	Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study
title_sort	prognostic value of bone formation and resorption proteins in heterotopic ossification in critically-ill patients. a single-centre study
publisher	Sciendo
series	The Journal of Critical Care Medicine
issn	2393-1817
publishDate	2021-01-01
description	A potential complication in critically ill patients is the formation of bone in soft tissues, termed heterotopic ossification. The exact pathogenetic mechanisms are still undetermined. Bone morphogenetic proteins induce bone formation, while signalling through the receptor activator of nuclear factor kappa-Β (RANK) and its ligand (RANKL), regulates osteoclast formation, activation, and survival in normal bone modelling and remodelling. Osteoprotegerin protects bone from excessive bone loss by blocking RANKL from binding to RANK.
topic	bone morphogenetic proteins critically-ill heterotropic ossification osteoprotegerin receptor activator of nuclear factor kappa-β ligand
url	https://doi.org/10.2478/jccm-2020-0046
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Prognostic Value of Bone Formation and Resorption Proteins in Heterotopic Ossification in Critically-Ill Patients. A Single-Centre Study

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