Regulatory roles of tRNA-derived RNA fragments in human pathophysiology

Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated...

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Main Authors:	Kush Kumar Pandey, Deeksha Madhry, Y.S. Ravi Kumar, Shivani Malvankar, Leena Sapra, Rupesh K. Srivastava, Sankar Bhattacharyya, Bhupendra Verma
Format:	Article
Language:	English
Published:	Elsevier 2021-12-01
Series:	Molecular Therapy: Nucleic Acids
Subjects:	sncRNA lncRNA tRFs tsRNA tiRNA tRNA processing
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253121001645

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spelling	doaj-0239bb94b63e4c398a1d62c7aa8f928c2021-09-03T04:44:32ZengElsevierMolecular Therapy: Nucleic Acids2162-25312021-12-0126161173Regulatory roles of tRNA-derived RNA fragments in human pathophysiologyKush Kumar Pandey0Deeksha Madhry1Y.S. Ravi Kumar2Shivani Malvankar3Leena Sapra4Rupesh K. Srivastava5Sankar Bhattacharyya6Bhupendra Verma7Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biotechnology, M.S. Ramaiah, Institute of Technology, MSR Nagar, Bengaluru, IndiaDepartment of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaDepartment of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, IndiaTranslational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, IndiaDepartment of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India; Corresponding author: Bhupendra Verma, Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated from precursor (pre-)tRNA or mature tRNA. They have been found to play crucial regulatory roles during different pathological conditions. Herein, we briefly summarize the discovery and recent advances in deciphering the regulatory role played by tRFs in the pathophysiology of different human diseases.http://www.sciencedirect.com/science/article/pii/S2162253121001645sncRNAlncRNAtRFstsRNAtiRNAtRNA processing
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kush Kumar Pandey Deeksha Madhry Y.S. Ravi Kumar Shivani Malvankar Leena Sapra Rupesh K. Srivastava Sankar Bhattacharyya Bhupendra Verma
spellingShingle	Kush Kumar Pandey Deeksha Madhry Y.S. Ravi Kumar Shivani Malvankar Leena Sapra Rupesh K. Srivastava Sankar Bhattacharyya Bhupendra Verma Regulatory roles of tRNA-derived RNA fragments in human pathophysiology Molecular Therapy: Nucleic Acids sncRNA lncRNA tRFs tsRNA tiRNA tRNA processing
author_facet	Kush Kumar Pandey Deeksha Madhry Y.S. Ravi Kumar Shivani Malvankar Leena Sapra Rupesh K. Srivastava Sankar Bhattacharyya Bhupendra Verma
author_sort	Kush Kumar Pandey
title	Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_short	Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_full	Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_fullStr	Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_full_unstemmed	Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_sort	regulatory roles of trna-derived rna fragments in human pathophysiology
publisher	Elsevier
series	Molecular Therapy: Nucleic Acids
issn	2162-2531
publishDate	2021-12-01
description	Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated from precursor (pre-)tRNA or mature tRNA. They have been found to play crucial regulatory roles during different pathological conditions. Herein, we briefly summarize the discovery and recent advances in deciphering the regulatory role played by tRFs in the pathophysiology of different human diseases.
topic	sncRNA lncRNA tRFs tsRNA tiRNA tRNA processing
url	http://www.sciencedirect.com/science/article/pii/S2162253121001645
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Regulatory roles of tRNA-derived RNA fragments in human pathophysiology

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