Regulatory roles of tRNA-derived RNA fragments in human pathophysiology

Regulatory roles of tRNA-derived RNA fragments in human pathophysiology

Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated...

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Bibliographic Details
Main Authors: Kush Kumar Pandey, Deeksha Madhry, Y.S. Ravi Kumar, Shivani Malvankar, Leena Sapra, Rupesh K. Srivastava, Sankar Bhattacharyya, Bhupendra Verma
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
sncRNA
lncRNA
tRFs
tsRNA
tiRNA
tRNA processing
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001645
Description
Summary:Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated from precursor (pre-)tRNA or mature tRNA. They have been found to play crucial regulatory roles during different pathological conditions. Herein, we briefly summarize the discovery and recent advances in deciphering the regulatory role played by tRFs in the pathophysiology of different human diseases.
ISSN:2162-2531

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