Alendronate Can Improve Bone Alterations in Experimental Diabetes by Preventing Antiosteogenic, Antichondrogenic, and Proadipocytic Effects of AGEs on Bone Marrow Progenitor Cells

Alendronate Can Improve Bone Alterations in Experimental Diabetes by Preventing Antiosteogenic, Antichondrogenic, and Proadipocytic Effects of AGEs on Bone Marrow Progenitor Cells

Bisphosphonates such as alendronate are antiosteoporotic drugs that inhibit the activity of bone-resorbing osteoclasts and secondarily promote osteoblastic function. Diabetes increases bone-matrix-associated advanced glycation end products (AGEs) that impair bone marrow progenitor cell (BMPC) osteog...

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Bibliographic Details
Main Authors:	Sara Rocío Chuguransky, Ana María Cortizo, Antonio Desmond McCarthy
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2016/5891925

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