The Persister Character of Clinical Isolates of Staphylococcus aureus Contributes to Faster Evolution to Resistance and Higher Survival in THP-1 Monocytes: A Study With Moxifloxacin

The Persister Character of Clinical Isolates of Staphylococcus aureus Contributes to Faster Evolution to Resistance and Higher Survival in THP-1 Monocytes: A Study With Moxifloxacin

Staphylococcus aureus may cause relapsing infections. We previously showed that S. aureus SH1000 surviving intracellularly to bactericidal antibiotics are persisters. Here, we used 54 non-duplicate clinical isolates to assess links between persistence, resistance evolution, and intracellular surviva...

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Bibliographic Details
Main Authors: Tiep K. Nguyen, Frédéric Peyrusson, Magali Dodémont, Nhung H. Pham, Hoang A. Nguyen, Paul M. Tulkens, Françoise Van Bambeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
Staphylococcus aureus
persister
intracellular infection
resistance
intracellular survival
moxifloxacin
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.587364/full

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