Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors.

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors.

The ataxia telangiectasia and Rad3-related (ATR) protein kinase is a key regulator of the cellular response to DNA damage. Due to increased amount of replication stress, cancer cells heavily rely on ATR to complete DNA replication and cell cycle progression. Thus, ATR inhibition is an emerging targe...

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Bibliographic Details
Main Authors: Emily M Schleicher, Ashna Dhoonmoon, Lindsey M Jackson, Kristen E Clements, Coryn L Stump, Claudia M Nicolae, George-Lucian Moldovan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009176

Internet

https://doi.org/10.1371/journal.pgen.1009176

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