T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation

T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation

Summary: IRF5 polymorphisms are associated with multiple immune-mediated diseases, including ulcerative colitis. IRF5 contributions are attributed to its role in myeloid lineages. How T cell-intrinsic IRF5 contributes to inflammatory outcomes is not well understood. We identify a previously undefine...

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Bibliographic Details
Main Authors: Jie Yan, Surya P. Pandey, Betsy J. Barnes, Jerrold R. Turner, Clara Abraham
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
T cells
colitis
IRF5
cytokines
T cell trafficking
inflammatory bowel disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308019

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