Structural basis of the activation of c-MET receptor

Structural basis of the activation of c-MET receptor

Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET...

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Main Authors: Emiko Uchikawa, Zhiming Chen, Guan-Yu Xiao, Xuewu Zhang, Xiao-chen Bai
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24367-3
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spelling doaj-021c698d2144460ea3a9ccd0134764dc2021-07-04T11:45:47ZengNature Publishing GroupNature Communications2041-17232021-07-0112111410.1038/s41467-021-24367-3Structural basis of the activation of c-MET receptorEmiko Uchikawa0Zhiming Chen1Guan-Yu Xiao2Xuewu Zhang3Xiao-chen Bai4Department of Biophysics, University of Texas Southwestern Medical CenterDepartment of Cell Biology, University of Texas Southwestern Medical CenterDepartment of Cell Biology, University of Texas Southwestern Medical CenterDepartment of Biophysics, University of Texas Southwestern Medical CenterDepartment of Biophysics, University of Texas Southwestern Medical CenterActivation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET activation.https://doi.org/10.1038/s41467-021-24367-3
collection DOAJ
language English
format Article
sources DOAJ
author Emiko Uchikawa
Zhiming Chen
Guan-Yu Xiao
Xuewu Zhang
Xiao-chen Bai
spellingShingle Emiko Uchikawa
Zhiming Chen
Guan-Yu Xiao
Xuewu Zhang
Xiao-chen Bai
Structural basis of the activation of c-MET receptor
Nature Communications
author_facet Emiko Uchikawa
Zhiming Chen
Guan-Yu Xiao
Xuewu Zhang
Xiao-chen Bai
author_sort Emiko Uchikawa
title Structural basis of the activation of c-MET receptor
title_short Structural basis of the activation of c-MET receptor
title_full Structural basis of the activation of c-MET receptor
title_fullStr Structural basis of the activation of c-MET receptor
title_full_unstemmed Structural basis of the activation of c-MET receptor
title_sort structural basis of the activation of c-met receptor
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET activation.
url https://doi.org/10.1038/s41467-021-24367-3
work_keys_str_mv AT emikouchikawa structuralbasisoftheactivationofcmetreceptor
AT zhimingchen structuralbasisoftheactivationofcmetreceptor
AT guanyuxiao structuralbasisoftheactivationofcmetreceptor
AT xuewuzhang structuralbasisoftheactivationofcmetreceptor
AT xiaochenbai structuralbasisoftheactivationofcmetreceptor
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