Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

Hundreds of genes interact with the yeast nuclear pore complex (NPC), localizing at the nuclear periphery and clustering with co-regulated genes. Dynamic tracking of peripheral genes shows that they cycle on and off the NPC and that interaction with the NPC slows their sub-diffusive movement. Furthe...

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Bibliographic Details
Main Authors: Michael Chas Sumner, Steven B Torrisi, Donna G Brickner, Jason H Brickner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
chromosome
nuclear pore complex
dynamics
nuclear architecture
transcription
clustering
Online Access:https://elifesciences.org/articles/66238

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