Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

Multi-region exome sequencing reveals the intratumoral heterogeneity of surgically resected small cell lung cancer

Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic bio...

Full description

Bibliographic Details
Main Authors: Huaqiang Zhou, Yi Hu, Rongzhen Luo, Yuanyuan Zhao, Hui Pan, Liyan Ji, Ting Zhou, Lanjun Zhang, Hao Long, Jianhua Fu, Zhesheng Wen, Siyu Wang, Xin Wang, Peng Lin, Haoxian Yang, Junye Wang, Mengmeng Song, Xin Yi, Ling Yang, Xuefang Xia, Yanfang Guan, Wenfeng Fang, Yunpeng Yang, Shaodong Hong, Yan Huang, Pansong Li, Yaxiong Zhang, Ningning Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25787-x
Description
Summary:Multi-region sequencing of small cell lung cancers (SCLC) can improve our understanding of the disease. Here the authors analyse 120 multi-region samples from 40 SCLC patients with whole exome sequencing and characterise their mutational burden, evolution, heterogeneity, and potential prognostic biomarkers.
ISSN:2041-1723

Similar Items