Ganglion cell complex thickness in screening of hydroxychloroquine maculopathy

Background Screening of early hydroxychloroquine (HCQ) maculopathy is important to prevent permanent structural and functional retinal damage. Spectral domain optical coherence tomography (SD-OCT) ultra-high-resolution imaging and speed allows better visualization of retinal architecture and measure...

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Main Authors: Yasmin M.M Amin, Moustafa K Nassar, Asmaa M Ibrahim
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Delta Journal of Ophthalmology
Subjects:
Online Access:http://www.djo.eg.net/article.asp?issn=1110-9173;year=2020;volume=21;issue=3;spage=187;epage=193;aulast=Amin
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spelling doaj-01fb622cc9524460a2d95868b43efb282021-10-06T13:47:25ZengWolters Kluwer Medknow PublicationsDelta Journal of Ophthalmology1110-91732090-48352020-01-0121318719310.4103/DJO.DJO_23_20Ganglion cell complex thickness in screening of hydroxychloroquine maculopathyYasmin M.M AminMoustafa K NassarAsmaa M IbrahimBackground Screening of early hydroxychloroquine (HCQ) maculopathy is important to prevent permanent structural and functional retinal damage. Spectral domain optical coherence tomography (SD-OCT) ultra-high-resolution imaging and speed allows better visualization of retinal architecture and measurement of the thickness of the retinal layers. Objective The aim of this study was to evaluate the macular ganglion cell complex (GCC) thickness by using SD-OCT for screening of early HCQ maculopathy. Patients and methods A total of 128 patients were included in the present study. They were divided into two groups: HCQ group, comprising 128 eyes of 64 patients treated with HCQ, and a control group, comprising 128 eyes of 64 healthy individuals. Average, minimum, and sectorial macular GCC thickness and photoreceptor layer (PL) integrity were compared between the two study groups. Correlations between GCC thickness and duration of HCQ use, PL integrity, uncorrected visual acuity, and best-corrected visual acuity in the HCQ group were analyzed. Results There were no statistically significant differences between the two groups regarding the average, minimum, and sectorial macular GCC thickness. However, a statistically significant difference between the two groups was found regarding the PL integrity. In addition, the PL integrity was found to have the highest independent correlation with the average macular GCC thickness, followed by the duration of treatment with HCQ, and lastly, the uncorrected visual acuity. Conclusion Unique SD-OCT findings in the retina can identify early HCQ retinopathy and may play a role as a complementary objective tool in HCQ maculopathy screening.http://www.djo.eg.net/article.asp?issn=1110-9173;year=2020;volume=21;issue=3;spage=187;epage=193;aulast=Aminganglion cell complexhydroxychloroquinemaculopathyphotoreceptor
collection DOAJ
language English
format Article
sources DOAJ
author Yasmin M.M Amin
Moustafa K Nassar
Asmaa M Ibrahim
spellingShingle Yasmin M.M Amin
Moustafa K Nassar
Asmaa M Ibrahim
Ganglion cell complex thickness in screening of hydroxychloroquine maculopathy
Delta Journal of Ophthalmology
ganglion cell complex
hydroxychloroquine
maculopathy
photoreceptor
author_facet Yasmin M.M Amin
Moustafa K Nassar
Asmaa M Ibrahim
author_sort Yasmin M.M Amin
title Ganglion cell complex thickness in screening of hydroxychloroquine maculopathy
title_short Ganglion cell complex thickness in screening of hydroxychloroquine maculopathy
title_full Ganglion cell complex thickness in screening of hydroxychloroquine maculopathy
title_fullStr Ganglion cell complex thickness in screening of hydroxychloroquine maculopathy
title_full_unstemmed Ganglion cell complex thickness in screening of hydroxychloroquine maculopathy
title_sort ganglion cell complex thickness in screening of hydroxychloroquine maculopathy
publisher Wolters Kluwer Medknow Publications
series Delta Journal of Ophthalmology
issn 1110-9173
2090-4835
publishDate 2020-01-01
description Background Screening of early hydroxychloroquine (HCQ) maculopathy is important to prevent permanent structural and functional retinal damage. Spectral domain optical coherence tomography (SD-OCT) ultra-high-resolution imaging and speed allows better visualization of retinal architecture and measurement of the thickness of the retinal layers. Objective The aim of this study was to evaluate the macular ganglion cell complex (GCC) thickness by using SD-OCT for screening of early HCQ maculopathy. Patients and methods A total of 128 patients were included in the present study. They were divided into two groups: HCQ group, comprising 128 eyes of 64 patients treated with HCQ, and a control group, comprising 128 eyes of 64 healthy individuals. Average, minimum, and sectorial macular GCC thickness and photoreceptor layer (PL) integrity were compared between the two study groups. Correlations between GCC thickness and duration of HCQ use, PL integrity, uncorrected visual acuity, and best-corrected visual acuity in the HCQ group were analyzed. Results There were no statistically significant differences between the two groups regarding the average, minimum, and sectorial macular GCC thickness. However, a statistically significant difference between the two groups was found regarding the PL integrity. In addition, the PL integrity was found to have the highest independent correlation with the average macular GCC thickness, followed by the duration of treatment with HCQ, and lastly, the uncorrected visual acuity. Conclusion Unique SD-OCT findings in the retina can identify early HCQ retinopathy and may play a role as a complementary objective tool in HCQ maculopathy screening.
topic ganglion cell complex
hydroxychloroquine
maculopathy
photoreceptor
url http://www.djo.eg.net/article.asp?issn=1110-9173;year=2020;volume=21;issue=3;spage=187;epage=193;aulast=Amin
work_keys_str_mv AT yasminmmamin ganglioncellcomplexthicknessinscreeningofhydroxychloroquinemaculopathy
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AT asmaamibrahim ganglioncellcomplexthicknessinscreeningofhydroxychloroquinemaculopathy
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