Inherent dynamics of head domain correlates with ATP-recognition of P2X4 receptors: insights gained from molecular simulations.

Inherent dynamics of head domain correlates with ATP-recognition of P2X4 receptors: insights gained from molecular simulations.

P2X receptors are ATP-gated ion channels involved in many physiological functions, and determination of ATP-recognition (AR) of P2X receptors will promote the development of new therapeutic agents for pain, inflammation, bladder dysfunction and osteoporosis. Recent crystal structures of the zebrafis...

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Bibliographic Details
Main Authors: Li-Dong Huang, Ying-Zhe Fan, Yun Tian, Yang Yang, Yan Liu, Jin Wang, Wen-Shan Zhao, Wen-Chao Zhou, Xiao-Yang Cheng, Peng Cao, Xiang-Yang Lu, Ye Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4039465?pdf=render

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http://europepmc.org/articles/PMC4039465?pdf=render

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