Update to: Application of Bayesian decision-making to laboratory testing for Lyme disease and comparison with testing for HIV

• Main Authors: Cook MJ, Puri BK
• Format: Article
• Language: English
• Published: Dove Medical Press 2017-09-01
• Series: International Journal of General Medicine
• Subjects: Lyme disease; Lyme borreliosis; Bayes Theorem; two-tier test; 2 tier test; test sensitivity; ELISA test; Western Blot test; HIV testing.
• Online Access: https://www.dovepress.com/update-to-application-of-bayesian-decision-making-to-laboratory-testin-peer-reviewed-article-IJGM

Michael J Cook,1 Basant K Puri21Independent researcher, Highcliffe, UK; 2Department of Medicine, Hammersmith Hospital, Imperial College London, London, UKIn our recent Bayesian analysis paper, false-negative results were compared between Lyme disease and HIV using a recommended test algorithm.1 When the two-tier test methodology for Lyme disease was compared with HIV two-stage testing, false negatives could be more than 500 times higher for Lyme disease testing.