Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease

Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease

Abstract Background Emerging data support a role for lipids in non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in humans. With experimental models such data can be challenged or validated. Mice fed a low-methionine, choline-deficient (LMCD) diet develop NASH and, when injecte...

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Bibliographic Details
Main Authors: Elisabeth M. Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Lipids in Health and Disease
Subjects:
Liver tumor
Ceramide
Phospholipids
Lipogenesis
Cholesterol
Diethylnitrosamine
Online Access:https://doi.org/10.1186/s12944-020-01425-1

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