Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7–NMDA Receptor Antagonists

Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7–NMDA Receptor Antagonists

Multi-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer’s Disease (AD). Herein, we present compounds aimed at targeting the NMDA and the P2X7 receptors, which embody a different approach to AD therapy. On one hand, we are seeking to...

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Bibliographic Details
Main Authors: Olga Karoutzou, Seung-Hwa Kwak, So-Deok Lee, Daina Martínez-Falguera, Francesc X. Sureda, Santiago Vázquez, Yong-Chul Kim, Marta Barniol-Xicota
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
Alzheimer’s disease
dual target compounds
neuroinflammation
NMDA
P2X7
Online Access:http://www.mdpi.com/1420-3049/23/1/230

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