Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-spec...

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Bibliographic Details
Main Authors: Michael Tong, Jeff G. Pelton, Michelle L. Gill, Weibing Zhang, Francis Picart, Markus A. Seeliger
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02240-6

Internet

https://doi.org/10.1038/s41467-017-02240-6

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