Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-spec...

Full description

Bibliographic Details
Main Authors:	Michael Tong, Jeff G. Pelton, Michelle L. Gill, Weibing Zhang, Francis Picart, Markus A. Seeliger
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02240-6

id	doaj-01dc8ef23c534552afe3e1801c1b9be5
record_format	Article
spelling	doaj-01dc8ef23c534552afe3e1801c1b9be52021-05-11T07:06:38ZengNature Publishing GroupNature Communications2041-17232017-12-018111510.1038/s41467-017-02240-6Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sitesMichael Tong0Jeff G. Pelton1Michelle L. Gill2Weibing Zhang3Francis Picart4Markus A. Seeliger5Department of Pharmacological Sciences, Stony Brook University Medical SchoolQB3 Institute, University of CaliforniaStructural Biophysics Laboratory, National Cancer InstituteDepartment of Pharmacological Sciences, Stony Brook University Medical SchoolDepartment of Chemistry, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook University Medical SchoolSrc is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics.https://doi.org/10.1038/s41467-017-02240-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michael Tong Jeff G. Pelton Michelle L. Gill Weibing Zhang Francis Picart Markus A. Seeliger
spellingShingle	Michael Tong Jeff G. Pelton Michelle L. Gill Weibing Zhang Francis Picart Markus A. Seeliger Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites Nature Communications
author_facet	Michael Tong Jeff G. Pelton Michelle L. Gill Weibing Zhang Francis Picart Markus A. Seeliger
author_sort	Michael Tong
title	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_short	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_full	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_fullStr	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_full_unstemmed	Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
title_sort	survey of solution dynamics in src kinase reveals allosteric cross talk between the ligand binding and regulatory sites
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Src is a prototypical signaling non-receptor protein tyrosine kinase that interconverts between distinct conformations. Here the authors use variants of the kinase-inhibitor dasatinib to define three specific conformational states of the Src kinase and shed insight on the effect of conformation-specific inhibitors on Src dynamics.
url	https://doi.org/10.1038/s41467-017-02240-6
work_keys_str_mv	AT michaeltong surveyofsolutiondynamicsinsrckinaserevealsallostericcrosstalkbetweentheligandbindingandregulatorysites AT jeffgpelton surveyofsolutiondynamicsinsrckinaserevealsallostericcrosstalkbetweentheligandbindingandregulatorysites AT michellelgill surveyofsolutiondynamicsinsrckinaserevealsallostericcrosstalkbetweentheligandbindingandregulatorysites AT weibingzhang surveyofsolutiondynamicsinsrckinaserevealsallostericcrosstalkbetweentheligandbindingandregulatorysites AT francispicart surveyofsolutiondynamicsinsrckinaserevealsallostericcrosstalkbetweentheligandbindingandregulatorysites AT markusaseeliger surveyofsolutiondynamicsinsrckinaserevealsallostericcrosstalkbetweentheligandbindingandregulatorysites
_version_	1721452757160820736

Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

Similar Items