Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference,...
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doaj-01dc6c95f58a4162bb14fa3ea697f6b42020-11-24T22:16:18ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/97820319782031Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep ApneaXiaoya Wang0Qin Yu1Hongmei Yue2Jiabin Zhang3Shuang Zeng4Fenfen Cui5Department of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou 730000, ChinaObjectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P<0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P<0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P<0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P<0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r=0.44, P<0.01), AEA and AHI (r=0.52, P<0.01), AEA and HOMA-IR (r=0.62, P<0.01), and 1/2-AG and HOMA-IR (r=0.33, P<0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA.http://dx.doi.org/10.1155/2016/9782031 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoya Wang Qin Yu Hongmei Yue Jiabin Zhang Shuang Zeng Fenfen Cui |
spellingShingle |
Xiaoya Wang Qin Yu Hongmei Yue Jiabin Zhang Shuang Zeng Fenfen Cui Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea BioMed Research International |
author_facet |
Xiaoya Wang Qin Yu Hongmei Yue Jiabin Zhang Shuang Zeng Fenfen Cui |
author_sort |
Xiaoya Wang |
title |
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_short |
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_full |
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_fullStr |
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_full_unstemmed |
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea |
title_sort |
circulating endocannabinoids and insulin resistance in patients with obstructive sleep apnea |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P<0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P<0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P<0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P<0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r=0.44, P<0.01), AEA and AHI (r=0.52, P<0.01), AEA and HOMA-IR (r=0.62, P<0.01), and 1/2-AG and HOMA-IR (r=0.33, P<0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA. |
url |
http://dx.doi.org/10.1155/2016/9782031 |
work_keys_str_mv |
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