Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea

Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference,...

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Main Authors: Xiaoya Wang, Qin Yu, Hongmei Yue, Jiabin Zhang, Shuang Zeng, Fenfen Cui
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2016/9782031
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spelling doaj-01dc6c95f58a4162bb14fa3ea697f6b42020-11-24T22:16:18ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/97820319782031Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep ApneaXiaoya Wang0Qin Yu1Hongmei Yue2Jiabin Zhang3Shuang Zeng4Fenfen Cui5Department of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College of Lanzhou University, Lanzhou 730000, ChinaObjectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P<0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P<0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P<0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P<0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r=0.44, P<0.01), AEA and AHI (r=0.52, P<0.01), AEA and HOMA-IR (r=0.62, P<0.01), and 1/2-AG and HOMA-IR (r=0.33, P<0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA.http://dx.doi.org/10.1155/2016/9782031
collection DOAJ
language English
format Article
sources DOAJ
author Xiaoya Wang
Qin Yu
Hongmei Yue
Jiabin Zhang
Shuang Zeng
Fenfen Cui
spellingShingle Xiaoya Wang
Qin Yu
Hongmei Yue
Jiabin Zhang
Shuang Zeng
Fenfen Cui
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
BioMed Research International
author_facet Xiaoya Wang
Qin Yu
Hongmei Yue
Jiabin Zhang
Shuang Zeng
Fenfen Cui
author_sort Xiaoya Wang
title Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_short Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_full Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_fullStr Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_full_unstemmed Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
title_sort circulating endocannabinoids and insulin resistance in patients with obstructive sleep apnea
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2016-01-01
description Objectives. The purpose of this study is to investigate the relationship between plasma endocannabinoids and insulin resistance (IR) in patients with obstructive sleep apnea (OSA). Methods. A population of 64 with OSA and 24 control subjects was recruited. Body mass index (BMI), waist circumference, lipids, blood glucose and insulin, homeostasis model of assessment for insulin resistance index (HOMA-IR), anandamide (AEA), 1/2-arachidonoylglycerol (1/2-AG), and apnea-hypopnea index (AHI) were analyzed. Results. Fasting blood insulin (22.9 ± 7.8 mIU/L versus 18.5 ± 7.2 mIU/L, P<0.05), HOMA-IR (2.9 ± 1.0 versus 2.4 ± 0.9, P<0.01), AEA (3.2 ± 0.7 nmol/L versus 2.5 ± 0.6 nmol/L, P<0.01), and 1/2-AG (40.8 ± 5.7 nmol/L versus 34.3 ± 7.7 nmol/L, P<0.01) were higher in OSA group than those in control group. In OSA group, AEA, 1/2-AG, and HOMA-IR increase with the OSA severity. The correlation analysis showed significant positive correlation between HOMA-IR and AHI (r=0.44, P<0.01), AEA and AHI (r=0.52, P<0.01), AEA and HOMA-IR (r=0.62, P<0.01), and 1/2-AG and HOMA-IR (r=0.33, P<0.01). Further analysis showed that only AEA was significantly correlated with AHI and HOMA-IR after adjusting for confounding factors. Conclusions. The present study indicated that plasma endocannabinoids levels, especially AEA, were associated with IR and AHI in patients with OSA.
url http://dx.doi.org/10.1155/2016/9782031
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