The Role of E27-K31 and E56-K10 Salt-Bridge Pairs in the Unfolding Mechanism of the B1 Domain of Protein G

The Role of E27-K31 and E56-K10 Salt-Bridge Pairs in the Unfolding Mechanism of the B1 Domain of Protein G

Molecular dynamics simulations of the B1 fragment of protein G (56 residues) have been performed at 325, 350, 375, 400, 450 and 500 K for 10 ns. An analysis of its structural and energetic parameters has indicated that the unfolding process of the GB1 protein begins at 900 ps of a 500-K simulation....

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Bibliographic Details
Main Authors: Tony Ibnu Sumaryada, Kania Nur Sawitri, Setyanto Tri Wahyudi
Format: Article
Language:English
Published: Universitas Gadjah Mada 2018-02-01
Series:Indonesian Journal of Chemistry
Subjects:
protein G
molecular dynamics
protein folding
hybrid model
salt-bridge pairs
Online Access:https://jurnal.ugm.ac.id/ijc/article/view/23934

Internet

https://jurnal.ugm.ac.id/ijc/article/view/23934

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