Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation

Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation

Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms....

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Main Authors: Montserrat Estruch, José Luis Sánchez-Quesada, Jordi Ordóñez Llanos, Sònia Benítez
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/181324
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spelling doaj-01c628be4ebf41a88a681d99ae5753802020-11-24T22:45:53ZengHindawi LimitedMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/181324181324Electronegative LDL: A Circulating Modified LDL with a Role in InflammationMontserrat Estruch0José Luis Sánchez-Quesada1Jordi Ordóñez Llanos2Sònia Benítez3Servei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau (IIB Sant Pau), 167 Sant Antoni Maria Claret, 08025 Barcelona, SpainServei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau (IIB Sant Pau), 167 Sant Antoni Maria Claret, 08025 Barcelona, SpainDepartament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Barcelona, SpainServei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau (IIB Sant Pau), 167 Sant Antoni Maria Claret, 08025 Barcelona, SpainElectronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(−) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(−) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(−) suggest that it could have a dual biological effect.http://dx.doi.org/10.1155/2013/181324
collection DOAJ
language English
format Article
sources DOAJ
author Montserrat Estruch
José Luis Sánchez-Quesada
Jordi Ordóñez Llanos
Sònia Benítez
spellingShingle Montserrat Estruch
José Luis Sánchez-Quesada
Jordi Ordóñez Llanos
Sònia Benítez
Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
Mediators of Inflammation
author_facet Montserrat Estruch
José Luis Sánchez-Quesada
Jordi Ordóñez Llanos
Sònia Benítez
author_sort Montserrat Estruch
title Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_short Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_full Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_fullStr Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_full_unstemmed Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_sort electronegative ldl: a circulating modified ldl with a role in inflammation
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2013-01-01
description Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(−) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(−) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(−) suggest that it could have a dual biological effect.
url http://dx.doi.org/10.1155/2013/181324
work_keys_str_mv AT montserratestruch electronegativeldlacirculatingmodifiedldlwitharoleininflammation
AT joseluissanchezquesada electronegativeldlacirculatingmodifiedldlwitharoleininflammation
AT jordiordonezllanos electronegativeldlacirculatingmodifiedldlwitharoleininflammation
AT soniabenitez electronegativeldlacirculatingmodifiedldlwitharoleininflammation
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