Understanding gene sequence variation in the context of transcription regulation in yeast.

DNA sequence polymorphism in a regulatory protein can have a widespread transcriptional effect. Here we present a computational approach for analyzing modules of genes with a common regulation that are affected by specific DNA polymorphisms. We identify such regulatory-linkage modules by integrating...

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Bibliographic Details
Main Authors: Irit Gat-Viks, Renana Meller, Martin Kupiec, Ron Shamir
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2794365?pdf=render