| Summary: | Abstract Objective An accurate forecasting of outbreaks of influenza-like illness (ILI) could support public health officials to suggest public health actions earlier. We investigated the performance of three different feature spaces in different models to forecast the weekly ILI rate in Syria using EWARS data from World Health Organization (WHO). Time series feature space was first used and we applied the seven models which are Naïve, Average, Seasonal naïve, drift, dynamic harmonic regression (Dhr), seasonal and trend decomposition using loess (STL) and TBATS. The Second feature space is like some state-of-the-art, which we named $$53-weeks-before\_52-first-order-difference$$ 53-weeks-before_52-first-order-difference feature space. The third one, we proposed and named $$n-years-before\_m-weeks-around$$ n-years-before_m-weeks-around (YnWm) feature space. Machine learning (ML) and deep learning (DL) model were applied to the second and third feature spaces (generalized linear model (GLM), support vector regression (SVR), gradient boosting (GB), random forest (RF) and long short term memory (LSTM)). Results It was indicated that the LSTM model of four layers with $$1-year-before\_4-weeks-around$$ 1-year-before_4-weeks-around feature space gave more accurate results than other models and reached the lowest MAPE of $$3.52\%$$ 3.52% and the lowest RMSE of 0.01662. I hope that this modelling methodology can be applied in other countries and therefore help prevent and control influenza worldwide.
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