Perspectives on Triple-Negative Breast Cancer: Current Treatment Strategies, Unmet Needs, and Potential Targets for Future Therapies

Perspectives on Triple-Negative Breast Cancer: Current Treatment Strategies, Unmet Needs, and Potential Targets for Future Therapies

Triple-negative breast cancer (TNBC), characterized by the absence or low expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2), is the most aggressive subtype of breast cancer. TNBC accounts for about 15% of breast cancer cases in the U....

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Bibliographic Details
Main Authors: Gagan K. Gupta, Amber L. Collier, Dasom Lee, Richard A. Hoefer, Vasilena Zheleva, Lauren L. Siewertsz van Reesema, Angela M. Tang-Tan, Mary L. Guye, David Z. Chang, Janet S. Winston, Billur Samli, Rick J. Jansen, Emanuel F. Petricoin, Matthew P. Goetz, Harry D. Bear, Amy H. Tang
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
triple-negative breast cancer (TNBC)
EGFR/K-RAS/SIAH signaling pathway
pathologic incomplete responders (pIR)
tumor-driving signaling pathways in TNBC
neoadjuvant chemotherapy (NACT)
residual cancer burden (RCB)
Online Access:https://www.mdpi.com/2072-6694/12/9/2392

Internet

https://www.mdpi.com/2072-6694/12/9/2392

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