Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.

Bibliographic Details
Main Authors:	Yuta Ogasawara, Jinglei Cheng, Tsuyako Tatematsu, Misaki Uchida, Omi Murase, Shogo Yoshikawa, Yuki Ohsaki, Toyoshi Fujimoto
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18153-w

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spelling	doaj-01aa050b4596409a8597336a1d2235312021-09-12T11:48:23ZengNature Publishing GroupNature Communications2041-17232020-09-0111111210.1038/s41467-020-18153-wLong-term autophagy is sustained by activation of CCTβ3 on lipid dropletsYuta Ogasawara0Jinglei Cheng1Tsuyako Tatematsu2Misaki Uchida3Omi Murase4Shogo Yoshikawa5Yuki Ohsaki6Toyoshi Fujimoto7Laboratory of Molecular Cell Biology, Research Institute for Diseases of Old Age, Juntendo University Graduate School of MedicineDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of MedicineDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of MedicineDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of MedicineDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of MedicineDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of MedicineDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of MedicineLaboratory of Molecular Cell Biology, Research Institute for Diseases of Old Age, Juntendo University Graduate School of MedicineThe source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.https://doi.org/10.1038/s41467-020-18153-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuta Ogasawara Jinglei Cheng Tsuyako Tatematsu Misaki Uchida Omi Murase Shogo Yoshikawa Yuki Ohsaki Toyoshi Fujimoto
spellingShingle	Yuta Ogasawara Jinglei Cheng Tsuyako Tatematsu Misaki Uchida Omi Murase Shogo Yoshikawa Yuki Ohsaki Toyoshi Fujimoto Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets Nature Communications
author_facet	Yuta Ogasawara Jinglei Cheng Tsuyako Tatematsu Misaki Uchida Omi Murase Shogo Yoshikawa Yuki Ohsaki Toyoshi Fujimoto
author_sort	Yuta Ogasawara
title	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_short	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_full	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_fullStr	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_full_unstemmed	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_sort	long-term autophagy is sustained by activation of cctβ3 on lipid droplets
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.
url	https://doi.org/10.1038/s41467-020-18153-w
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Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

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