Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation

A library of thirty eight novel thiazolo[5,4-f]quinazolin-9(8H)-one derivatives (series 8, 10, 14 and 17) was prepared via the Hügershoff reaction and a Cu catalyzed intramolecular C-S bond formation, helped by microwave-assisted technology when required. The efficient multistep synthesis of the key...

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Bibliographic Details
Main Authors: Damien Hédou, Carole Dubouilh-Benard, Nadège Loaëc, Laurent Meijer, Corinne Fruit, Thierry Besson
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
Hügershoff reaction
thiazolo[5,4-f]quinazolin-9(8H)-ones
microwave-assisted synthesis
protein kinases
CDK5
GSK-3
CLK1
CK1
DYRK1A
Online Access:http://www.mdpi.com/1420-3049/21/6/794

Internet

http://www.mdpi.com/1420-3049/21/6/794

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