Genetic Cross-Talk During Head Development in Drosophila
The dorsal head vertex of Drosophila is specified mainly by the orthodenticle (otd) gene. The expression and the function of otd are regulated by the concerted action of many genes including hedgehog (hh) and notch (N). These genes are components of a meshwork of signaling transduction pathways that...
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Hindawi Limited
2004-01-01
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| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/S1110724304302032 |
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doaj-01a77393f92b4527ab373ed6ddd472d32020-11-25T01:27:36ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512004-01-0120041162310.1155/S1110724304302032Genetic Cross-Talk During Head Development in DrosophilaAmr Amin0Biology Department, Faculty of Science, University of UAE, PO Box 17551, Al Ain, United Arab EmiratesThe dorsal head vertex of Drosophila is specified mainly by the orthodenticle (otd) gene. The expression and the function of otd are regulated by the concerted action of many genes including hedgehog (hh) and notch (N). These genes are components of a meshwork of signaling transduction pathways that interact to form the dorsal head capsule of the fruit fly. Loss-of-function Hh mutants lack ocelli; however, loss-of-function N mutants lack a different domain of the dorsal head vertex. This report provides new evidence that the Hh and N pathways are two epistatic signaling cascades that act genetically upstream of the dorsal head capsule specification gene.http://dx.doi.org/10.1155/S1110724304302032 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Amr Amin |
| spellingShingle |
Amr Amin Genetic Cross-Talk During Head Development in Drosophila Journal of Biomedicine and Biotechnology |
| author_facet |
Amr Amin |
| author_sort |
Amr Amin |
| title |
Genetic Cross-Talk During Head Development in Drosophila |
| title_short |
Genetic Cross-Talk During Head Development in Drosophila |
| title_full |
Genetic Cross-Talk During Head Development in Drosophila |
| title_fullStr |
Genetic Cross-Talk During Head Development in Drosophila |
| title_full_unstemmed |
Genetic Cross-Talk During Head Development in Drosophila |
| title_sort |
genetic cross-talk during head development in drosophila |
| publisher |
Hindawi Limited |
| series |
Journal of Biomedicine and Biotechnology |
| issn |
1110-7243 1110-7251 |
| publishDate |
2004-01-01 |
| description |
The dorsal head vertex of Drosophila is specified
mainly by the orthodenticle (otd) gene. The
expression and the function of otd are regulated by the
concerted action of many genes including hedgehog
(hh) and notch (N). These genes are
components of a meshwork of signaling transduction pathways that
interact to form the dorsal head capsule of the fruit fly.
Loss-of-function Hh mutants lack ocelli; however,
loss-of-function N mutants lack a different domain of
the dorsal head vertex. This report provides new evidence that
the Hh and N pathways are two epistatic
signaling cascades that act genetically upstream of the dorsal
head capsule specification gene. |
| url |
http://dx.doi.org/10.1155/S1110724304302032 |
| work_keys_str_mv |
AT amramin geneticcrosstalkduringheaddevelopmentindrosophila |
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