A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila.

A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila.

The small GTPase RAS is among the most prevalent oncogenes. The evolutionarily conserved RAF-MEK-MAPK module that lies downstream of RAS is one of the main conduits through which RAS transmits proliferative signals in normal and cancer cells. Genetic and biochemical studies conducted over the last t...

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Bibliographic Details
Main Authors: Dariel Ashton-Beaucage, Christian M Udell, Patrick Gendron, Malha Sahmi, Martin Lefrançois, Caroline Baril, Anne-Sophie Guenier, Jean Duchaine, Daniel Lamarre, Sébastien Lemieux, Marc Therrien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3958334?pdf=render

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http://europepmc.org/articles/PMC3958334?pdf=render

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