An Effective Delivery System of Sitagliptin Using Optimized Mucoadhesive Nanoparticles

An Effective Delivery System of Sitagliptin Using Optimized Mucoadhesive Nanoparticles

Sitagliptin (MK-0431), is a potent oral hypoglycemic drug that is used for treating type 2 diabetes mellitus. However, the short half-life of sitagliptin requires patients to take a high dose of 50 mg twice per day, and the fraction of sitagliptin reversibly bound to plasma proteins is as low as 38%...

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Bibliographic Details
Main Authors: Afzal Haq Asif, Sree Harsha, Niranjan Hodalur Puttaswamy, Bandar E. Al-Dhubiab
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Applied Sciences
Subjects:
sitagliptin
diabetes mellitus
nanoparticle
mucoadhesive
Online Access:http://www.mdpi.com/2076-3417/8/6/861

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