Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila

The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less...

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Main Authors:	Sergey V. Ulianov, Semen A. Doronin, Ekaterina E. Khrameeva, Pavel I. Kos, Artem V. Luzhin, Sergei S. Starikov, Aleksandra A. Galitsyna, Valentina V. Nenasheva, Artem A. Ilyin, Ilya M. Flyamer, Elena A. Mikhaleva, Mariya D. Logacheva, Mikhail S. Gelfand, Alexander V. Chertovich, Alexey A. Gavrilov, Sergey V. Razin, Yuri Y. Shevelyov
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09185-y

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spelling	doaj-019c5aaf61ed41efb63d52b8af38836b2021-05-11T12:22:53ZengNature Publishing GroupNature Communications2041-17232019-03-0110111110.1038/s41467-019-09185-yNuclear lamina integrity is required for proper spatial organization of chromatin in DrosophilaSergey V. Ulianov0Semen A. Doronin1Ekaterina E. Khrameeva2Pavel I. Kos3Artem V. Luzhin4Sergei S. Starikov5Aleksandra A. Galitsyna6Valentina V. Nenasheva7Artem A. Ilyin8Ilya M. Flyamer9Elena A. Mikhaleva10Mariya D. Logacheva11Mikhail S. Gelfand12Alexander V. Chertovich13Alexey A. Gavrilov14Sergey V. Razin15Yuri Y. Shevelyov16Institute of Gene Biology, Russian Academy of SciencesInstitute of Molecular Genetics, Russian Academy of SciencesSkolkovo Institute of Science and TechnologyFaculty of Physics, M.V. Lomonosov Moscow State UniversityInstitute of Gene Biology, Russian Academy of SciencesFaculty of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State UniversityInstitute of Gene Biology, Russian Academy of SciencesInstitute of Molecular Genetics, Russian Academy of SciencesInstitute of Molecular Genetics, Russian Academy of SciencesMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of EdinburghInstitute of Molecular Genetics, Russian Academy of SciencesSkolkovo Institute of Science and TechnologySkolkovo Institute of Science and TechnologyFaculty of Physics, M.V. Lomonosov Moscow State UniversityInstitute of Gene Biology, Russian Academy of SciencesInstitute of Gene Biology, Russian Academy of SciencesInstitute of Molecular Genetics, Russian Academy of SciencesThe role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.https://doi.org/10.1038/s41467-019-09185-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sergey V. Ulianov Semen A. Doronin Ekaterina E. Khrameeva Pavel I. Kos Artem V. Luzhin Sergei S. Starikov Aleksandra A. Galitsyna Valentina V. Nenasheva Artem A. Ilyin Ilya M. Flyamer Elena A. Mikhaleva Mariya D. Logacheva Mikhail S. Gelfand Alexander V. Chertovich Alexey A. Gavrilov Sergey V. Razin Yuri Y. Shevelyov
spellingShingle	Sergey V. Ulianov Semen A. Doronin Ekaterina E. Khrameeva Pavel I. Kos Artem V. Luzhin Sergei S. Starikov Aleksandra A. Galitsyna Valentina V. Nenasheva Artem A. Ilyin Ilya M. Flyamer Elena A. Mikhaleva Mariya D. Logacheva Mikhail S. Gelfand Alexander V. Chertovich Alexey A. Gavrilov Sergey V. Razin Yuri Y. Shevelyov Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila Nature Communications
author_facet	Sergey V. Ulianov Semen A. Doronin Ekaterina E. Khrameeva Pavel I. Kos Artem V. Luzhin Sergei S. Starikov Aleksandra A. Galitsyna Valentina V. Nenasheva Artem A. Ilyin Ilya M. Flyamer Elena A. Mikhaleva Mariya D. Logacheva Mikhail S. Gelfand Alexander V. Chertovich Alexey A. Gavrilov Sergey V. Razin Yuri Y. Shevelyov
author_sort	Sergey V. Ulianov
title	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_short	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_full	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_fullStr	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_full_unstemmed	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_sort	nuclear lamina integrity is required for proper spatial organization of chromatin in drosophila
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-03-01
description	The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.
url	https://doi.org/10.1038/s41467-019-09185-y
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Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila

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