In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.

In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.

Dendritic cells (DCs) are phagocytes that are highly specialized for antigen presentation. Heterogeneous populations of macrophages and DCs form a phagocyte network inside the red pulp (RP) of the spleen, which is a major site for the control of blood-borne infections such as malaria. However, the d...

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Main Authors: Henrique Borges da Silva, Raíssa Fonseca, Alexandra Dos Anjos Cassado, Érika Machado de Salles, Maria Nogueira de Menezes, Jean Langhorne, Katia Regina Perez, Iolanda Midea Cuccovia, Bernhard Ryffel, Vasco M Barreto, Cláudio Romero Farias Marinho, Silvia Beatriz Boscardin, José Maria Álvarez, Maria Regina D'Império-Lima, Carlos Eduardo Tadokoro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004598

Internet

https://doi.org/10.1371/journal.ppat.1004598

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