Sleep disorders in Parkinson's disease
Nocturnal sleep disorders are common and clinically significant neuropsychic manifestations of Parkinson's disease (PD).Objective: to specify the clinical features of sleep disorders in patients with PD and to evaluate the impact of dopaminergic therapy on the basic characteristics of sleep and...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2011-03-01
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| Series: | Nevrologiâ, Nejropsihiatriâ, Psihosomatika |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/74 |
| Summary: | Nocturnal sleep disorders are common and clinically significant neuropsychic manifestations of Parkinson's disease (PD).Objective: to specify the clinical features of sleep disorders in patients with PD and to evaluate the impact of dopaminergic therapy on the basic characteristics of sleep and its related symptoms of the disease.Subjects and methods. Sixty-seven PD patients without dementia (mean age 63.2±9.9 years; mean PD duration 6.5±4.2 years) were followed up. Forty patients received pramipexole in a daily dose of 2.64±0.6 mg in addition to other dopaminergic agents. The unified PD rating scale (UPDRS), the PD sleep scale (PDSS), the Beck depression inventory and PD fatigue scale (PFS-16), the scales for outcomes of PD-cognition (SCOPA-Cog), and the PD quality of life scale (PDQ-39) were used.Results. Sleep fragmentation and early morning awakenings are the most common sleep disorders in PD. Pramipexole therapy resulted in a significant improvement in sleep quality, a reduction in the frequency of falling asleep and nocturnal awakenings. The improved characteristics of sleep were favored by a therapy-induced decrease in the severity of motor (hypokinesis, rigidity, tremor, nocturnal and morning dystonia) and nonmotor (restless legs syndrome/acathisia, sensory disorders, nocturia) PD manifestations. |
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| ISSN: | 2074-2711 2310-1342 |