Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation

Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation

T cell differentiation to effector Th cells such as Th1 and Th2 requires the integration of multiple synergic and antagonist signals. Poly(ADP-ribosy)lation is a posttranslational modification of proteins catalyzed by Poly(ADP-ribose) polymerases (PARPs). Recently, many reports showed that PARP-1, t...

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Bibliographic Details
Main Authors:	M. Sambucci, F. Laudisi, F. Novelli, E. Bennici, M. M. Rosado, C. Pioli
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2013/375024

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