Transcriptional response of polycomb group genes to status epilepticus in mice is modified by prior exposure to epileptic preconditioning

Transcriptional response of polycomb group genes to status epilepticus in mice is modified by prior exposure to epileptic preconditioning

Exposure of the brain to brief, non-harmful seizures can activate protective mechanisms that temporarily generate a damage-refractory state. This process, termed epileptic tolerance, is associated with large-scale down-regulation of gene expression. Polycomb group proteins are master controllers of...

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Bibliographic Details
Main Authors: James eReynolds, Suzanne eMiller-Delaney, Eva Maria Jimenez-Mateos, Takanori eSano, Ross eMcKiernan, Roger eSimon, David eHenshall
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Neurology
Subjects:
epigenetics
Neuroprotection
Epileptogenesis
Temporal Lobe Epilepsy
Seizure preconditionining
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00046/full

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