Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes

The inclusion of biofunctional molecules with synthetic bone graft substitutes has the potential to enhance tissue regeneration during treatment of traumatic bone injuries. The clinical use of growth factors has though been associated with complications, some serious. The use of smaller, active pept...

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Main Authors: George Bullock, Joss Atkinson, Piergiorgio Gentile, Paul Hatton, Cheryl Miller
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Journal of Functional Biomaterials
Subjects:
Online Access:https://www.mdpi.com/2079-4983/12/2/22
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spelling doaj-01850882e3034ddc9e5a8010170109312021-03-31T23:02:57ZengMDPI AGJournal of Functional Biomaterials2079-49832021-03-0112222210.3390/jfb12020022Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft SubstitutesGeorge Bullock0Joss Atkinson1Piergiorgio Gentile2Paul Hatton3Cheryl Miller4School of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKSchool of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKSchool of Engineering, Newcastle University, Stephenson Building, Newcastle upon Tyne NE1 7RU, UKSchool of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKSchool of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKThe inclusion of biofunctional molecules with synthetic bone graft substitutes has the potential to enhance tissue regeneration during treatment of traumatic bone injuries. The clinical use of growth factors has though been associated with complications, some serious. The use of smaller, active peptides has the potential to overcome these problems and provide a cost-effective, safe route for the manufacture of enhanced bone graft substitutes. This review considers the design of peptide-enhanced bone graft substitutes, and how peptide selection and attachment method determine clinical efficacy. It was determined that covalent attachment may reduce the known risks associated with growth factor-loaded bone graft substitutes, providing a predictable tissue response and greater clinical efficacy. Peptide choice was found to be critical, but even within recognised families of biologically active peptides, the configurations that appeared to most closely mimic the biological molecules involved in natural bone healing processes were most potent. It was concluded that rational, evidence-based design of peptide-enhanced bone graft substitutes offers a pathway to clinical maturity in this highly promising field.https://www.mdpi.com/2079-4983/12/2/22bone repair materialbiomimetic peptidessurface functionalisationtissue engineering
collection DOAJ
language English
format Article
sources DOAJ
author George Bullock
Joss Atkinson
Piergiorgio Gentile
Paul Hatton
Cheryl Miller
spellingShingle George Bullock
Joss Atkinson
Piergiorgio Gentile
Paul Hatton
Cheryl Miller
Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes
Journal of Functional Biomaterials
bone repair material
biomimetic peptides
surface functionalisation
tissue engineering
author_facet George Bullock
Joss Atkinson
Piergiorgio Gentile
Paul Hatton
Cheryl Miller
author_sort George Bullock
title Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes
title_short Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes
title_full Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes
title_fullStr Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes
title_full_unstemmed Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes
title_sort osteogenic peptides and attachment methods determine tissue regeneration in modified bone graft substitutes
publisher MDPI AG
series Journal of Functional Biomaterials
issn 2079-4983
publishDate 2021-03-01
description The inclusion of biofunctional molecules with synthetic bone graft substitutes has the potential to enhance tissue regeneration during treatment of traumatic bone injuries. The clinical use of growth factors has though been associated with complications, some serious. The use of smaller, active peptides has the potential to overcome these problems and provide a cost-effective, safe route for the manufacture of enhanced bone graft substitutes. This review considers the design of peptide-enhanced bone graft substitutes, and how peptide selection and attachment method determine clinical efficacy. It was determined that covalent attachment may reduce the known risks associated with growth factor-loaded bone graft substitutes, providing a predictable tissue response and greater clinical efficacy. Peptide choice was found to be critical, but even within recognised families of biologically active peptides, the configurations that appeared to most closely mimic the biological molecules involved in natural bone healing processes were most potent. It was concluded that rational, evidence-based design of peptide-enhanced bone graft substitutes offers a pathway to clinical maturity in this highly promising field.
topic bone repair material
biomimetic peptides
surface functionalisation
tissue engineering
url https://www.mdpi.com/2079-4983/12/2/22
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AT jossatkinson osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes
AT piergiorgiogentile osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes
AT paulhatton osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes
AT cherylmiller osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes
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