Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes
The inclusion of biofunctional molecules with synthetic bone graft substitutes has the potential to enhance tissue regeneration during treatment of traumatic bone injuries. The clinical use of growth factors has though been associated with complications, some serious. The use of smaller, active pept...
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doaj-01850882e3034ddc9e5a8010170109312021-03-31T23:02:57ZengMDPI AGJournal of Functional Biomaterials2079-49832021-03-0112222210.3390/jfb12020022Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft SubstitutesGeorge Bullock0Joss Atkinson1Piergiorgio Gentile2Paul Hatton3Cheryl Miller4School of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKSchool of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKSchool of Engineering, Newcastle University, Stephenson Building, Newcastle upon Tyne NE1 7RU, UKSchool of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKSchool of Clinical Dentistry, The University of Sheffield, Sheffield S10 2TA, UKThe inclusion of biofunctional molecules with synthetic bone graft substitutes has the potential to enhance tissue regeneration during treatment of traumatic bone injuries. The clinical use of growth factors has though been associated with complications, some serious. The use of smaller, active peptides has the potential to overcome these problems and provide a cost-effective, safe route for the manufacture of enhanced bone graft substitutes. This review considers the design of peptide-enhanced bone graft substitutes, and how peptide selection and attachment method determine clinical efficacy. It was determined that covalent attachment may reduce the known risks associated with growth factor-loaded bone graft substitutes, providing a predictable tissue response and greater clinical efficacy. Peptide choice was found to be critical, but even within recognised families of biologically active peptides, the configurations that appeared to most closely mimic the biological molecules involved in natural bone healing processes were most potent. It was concluded that rational, evidence-based design of peptide-enhanced bone graft substitutes offers a pathway to clinical maturity in this highly promising field.https://www.mdpi.com/2079-4983/12/2/22bone repair materialbiomimetic peptidessurface functionalisationtissue engineering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
George Bullock Joss Atkinson Piergiorgio Gentile Paul Hatton Cheryl Miller |
spellingShingle |
George Bullock Joss Atkinson Piergiorgio Gentile Paul Hatton Cheryl Miller Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes Journal of Functional Biomaterials bone repair material biomimetic peptides surface functionalisation tissue engineering |
author_facet |
George Bullock Joss Atkinson Piergiorgio Gentile Paul Hatton Cheryl Miller |
author_sort |
George Bullock |
title |
Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes |
title_short |
Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes |
title_full |
Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes |
title_fullStr |
Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes |
title_full_unstemmed |
Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes |
title_sort |
osteogenic peptides and attachment methods determine tissue regeneration in modified bone graft substitutes |
publisher |
MDPI AG |
series |
Journal of Functional Biomaterials |
issn |
2079-4983 |
publishDate |
2021-03-01 |
description |
The inclusion of biofunctional molecules with synthetic bone graft substitutes has the potential to enhance tissue regeneration during treatment of traumatic bone injuries. The clinical use of growth factors has though been associated with complications, some serious. The use of smaller, active peptides has the potential to overcome these problems and provide a cost-effective, safe route for the manufacture of enhanced bone graft substitutes. This review considers the design of peptide-enhanced bone graft substitutes, and how peptide selection and attachment method determine clinical efficacy. It was determined that covalent attachment may reduce the known risks associated with growth factor-loaded bone graft substitutes, providing a predictable tissue response and greater clinical efficacy. Peptide choice was found to be critical, but even within recognised families of biologically active peptides, the configurations that appeared to most closely mimic the biological molecules involved in natural bone healing processes were most potent. It was concluded that rational, evidence-based design of peptide-enhanced bone graft substitutes offers a pathway to clinical maturity in this highly promising field. |
topic |
bone repair material biomimetic peptides surface functionalisation tissue engineering |
url |
https://www.mdpi.com/2079-4983/12/2/22 |
work_keys_str_mv |
AT georgebullock osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes AT jossatkinson osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes AT piergiorgiogentile osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes AT paulhatton osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes AT cherylmiller osteogenicpeptidesandattachmentmethodsdeterminetissueregenerationinmodifiedbonegraftsubstitutes |
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1724177104398974976 |